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Ananth, C.V., Platt, R.W. and Savitz, D.A. (2005) Regression models for clustered binary responses: Implications of ignoring the intracluster correlation in an analysis of perinatal mortality in twin gestations. Annals of Epidemiology, 15, 293-301. doi:10.1016/j.annepidem.2004.08.007

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• TITLE: Perinatal morbidity and early neonatal mortality in twin pregnancies

  AUTHORS: Corinna Peter, Paul Wenzlaff, Jan Kruempelmann, Gerhard Alzen, Eva Bueltmann, Susanne E. Gruessner

  KEYWORDS: Twins; Chorionicity; Obstetric Outcome; Perinatal Morbidity; Early Neonatal Outcome

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.3 No.1, January 25, 2013

  ABSTRACT: Purpose: The purpose of this study was to investigate the impact of maternal, fetal and obstetric parameters in twin pregnancies due to chorionicity, perinatal morbidity and early neonatal mortality. Methods: Early neonatal outcome parameters were retrospectively analysed in 240 twin pregnancies (51 monochorionic [MC], 189 dichorionic [DC] twins) over a 7.5 years period. Beside chorionicity, we focused on risk factors affecting perinatal morbidity and early neonatal outcome in the overall study cohort and subgroups 1) late preterm and 2) pregnancies conceived by artificial fertilization (IVF/ICSI). Mixed effects logistic regression models were used for multivariate risk analyses. Results: MC vs DC pregnancies showed significantly lower birth weights (p 25% and amniotic inflammation (amniotic infection syndrome [AIS]). A gestational age >36 completed weeks was accompanied by a decrease of early neonatal complications (p