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Pandolfi, P., Sonati, F., Rivi, R., Mason, P., Grosveld, F. and Luzzatto, L. (1995) Targeted disruption of the housekeeping gene encoding glucose-6-phosphate- dehydrogenase (G6pd)-G6pd is dispensable for pentose synthesis but essential for defense against oxidative stress. Embo Journal, 14, 5209-5215.

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• TITLE: Enzymatic and histopathologic biomarkers as indicators of aquatic pollution in fishes

  AUTHORS: Alaa G. M. Osman, Abd-El –Baset M. Abd El Reheem, Khalid Y. AbuelFadl, Ali G. GadEl- Rab

  KEYWORDS: Metabolic enzyme; Histopathology; Biomarker; aquatic pollution; Rive Nile; African catfish

  JOURNAL NAME: Natural Science, Vol.2 No.11, November 30, 2010

  ABSTRACT: In the present study we investigated the alteration in the activity of two metabolic enzymes [Glucose-6-Phosphate Dehydrogenase (G6PDH) and Lactate Dehydrogenase (LDH)] and the histological changes on liver and gills of the African catfish Clarias gariepinus collected from 6 sites along the river Nile, from its spring at Aswan to its estuary at Rosetta and Damietta branches. The results showed that the physical and chemical parameters of the water collected from Damietta and Rosetta branches were higher than those of the water collected from other sites. Remarkable alterations in the activity of the selected enzymes in the liver and muscles of the African catfish were detected. These alterations go in parallel with the elevation in the levels of chemical parameters detected in the water of Damietta and Rosetta branches as a result of pollution stress in these areas. The activity of G6PDH was significantly (p