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G. Casadesus, M. A. Smith, S. Basu, J. Hua, D. E. Capobianco, S. L. Siedlak, X. Zhu, and G. Perry, (2007) Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease, Mol Neurodegener, 2(2).

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• TITLE: Geometrical study on diseaserelated ncRNAs based on Z-curve method

  AUTHORS: Yan-Ling Yang, Ji-Hua Wang

  KEYWORDS: Non-CodingRNA; Alzheimer Disease; snoRNA; miRNA; Z-Curve

  JOURNAL NAME: Health, Vol.1 No.1, June 3, 2009

  ABSTRACT: The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.