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Y. Ishii, Y. Hattori, T. Yamada, S. Uesato, Y. Maitani and Y. Nagaoka, “Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells,” European Journal of Medicinal Chemistry, Vol. 44, No. 11, 2009, pp. 4603-4610. doi:10.1016/j.ejmech.2009.06.036

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• TITLE: Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

  AUTHORS: Mytych Jennifer, Wnuk Maciej

  KEYWORDS: Nanoparticles; Nanotoxicology; Genotoxicity; Cytotoxicity; Epigenetics

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.4 No.1, January 23, 2013

  ABSTRACT: Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.