Article citationsMore>>
P. Rad-hakrishnan, D. V. Subbarao, K. V. Surendranath, D. Subrah-manyam and V. Himabindu, “A Validated LC Method for Determination of the Enantiomeric Purity of Montelukast Sodium in Bulk Drug Samples and Pharma- ceutical Dosage Forms,” Chromatographia, Vol. 68, No. 3-4, 2008, pp. 263-267.
has been cited by the following article:
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TITLE:
Isolation and Characterization of S-Enantiomer in Montelukast
AUTHORS:
Vijaya Lakshmi Maddala, Kishore Kumar Kakumani, Kameswara Rao Chimalakonda, Srinivasulu Polisetty, P. C. Ray
KEYWORDS:
(S)-Isomer; Montelukast; Supercritical Fluid Chromatography (SFC)
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.4 No.1,
January
22,
2013
ABSTRACT: A simple and rapid Supercritical Fluid Chromatography (SFC)
Method has been developed to isolate and characterize the S-Isomer of Montelukast
by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column
using a mobile phase system containing super critical fluid carbon dioxide (CO2)
and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230
nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H
NMR. The purity of isolated S-Isomer is about 98%.