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Mcgill, M.R., Sharpe, M.R., Williams, C.D., Taha, M., Curry, S.C. and Jaeschke, H. (2012) The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. The Journal of Clinical Investigation, 122, 1574-1583. doi:10.1172/JCI59755

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• TITLE: Bone-marrow derived cells participate in extramedullary hematopoiesis in a model of acetaminophen-induced acute liver failure in rats

  AUTHORS: Maria Cristina Belardinelli, Mónica López, Talita Giacomet de Carvalho, Fabiana Mayer, Guilherme Baldo, Luise Meurer, Roberto Giugliani, Ursula Matte

  KEYWORDS: Extramedullary Hematopoiesis; Bone Marrow Cells; Acute Liver Failure; Acetaminophen

  JOURNAL NAME: Stem Cell Discovery, Vol.3 No.1, January 22, 2013

  ABSTRACT: Adult derived mononuclear bone marrow cells are a good alternative as cell therapy. These cells are capable of significantly improve survival rate of Wistar rats with acetaminophen (APAP) induced acute liver failure in ten days. However, long term of cell therapy is not deeply studied in the literature. Here, we report an extramedullary hematopoiesis process derived from transplanted mononuclear bone marrow cells in the liver of rats 10 days after APAP injection. This result indicates that liver maintains an adequate microenvironment for the occurrence of extramedullary hematopoiesis process. The consequence of this finding deserves more studies.