TITLE:
Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization
AUTHORS:
Claudia Garnero, Carolina Aloisio, Marcela Longhi
KEYWORDS:
Ibuprofen; Maltodextrin; Chiral Recognition; Complex Characterization; Nuclear Magnetic Resonance Spectroscopy; Solubility Studies
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.4 No.1,
January
18,
2013
ABSTRACT: The interaction
between ibuprofen and maltodextrins with different dextrose equivalent was studied
in solution and solid state in order to investigate the effect on the solubility
of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent
binding constants were calculated using nuclear magnetic resonance spectroscopy
experiments and solubility studies. The results showed an increase in the apparent
solubility of ibuprofen in the presence of maltodextrins that depended on their
ionization state. The freeze-drying method was used to prepare solid complexes,
while physical mixtures were obtained by simple blending. These solid systems were
characterized in the solid state using differential scanning calorimetry, thermogravimetric analysis, Fourier Transform-Infrared spectroscopy, scanning electron
microscopy and X-ray diffractometry. Detailed nuclear magnetic resonance
studies provided evidence of the influence of the type and concentration of the
maltodextrin host on the chiral recognition of racemic ibuprofen, indicating that these linear ligands
act as chiral selectors.