TITLE:
Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity
AUTHORS:
S. I. Kisil, V. A. Chernikov, M. I. Danilevskiy, L. V. Savvateeva, N. V. Gorokhovets
KEYWORDS:
Alpha-fetoprotein; Dendrimer; Doxorubicin; Targeted Delivery
JOURNAL NAME:
Engineering,
Vol.4 No.10B,
January
17,
2013
ABSTRACT: The recombinant third domain of alpha-fetoprotein
(AFP3D) is one of the promising vectors for targeted delivery of anticancer
drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents
have shown specific anti-tumor activity. The content of anti-tumor drugs in the
preparation could be increased by including dendrimers - highly branched
nanoparticles - into a targeted delivery system. In this study, we synthesized
the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer
nanoparticles and investigated its cytotoxic activity.