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T. Yoshioka, S. Yoshida, T. Kurosaki, M. Teshima, K. Nishida, J. Nakamura, M. Nakashima, H. To, T. Kitahara and H. Sasaki, “Cationic liposomes-mediated plasmid DNA delivery in murine hepatitis induced by carbon tetrachloride,” J. Liposome Res. vol. 19, pp. 141-147, June 2009.

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• TITLE: In Vitro Study of Carbamate-Linked Cationic Lipid for Gene Delivery Against Cervical Cancer Cells

  AUTHORS: Defu Zhi, Shuibao Zhang, Yinan Zhao, Shaohui Cui, Bing Wang, Huiying Chen, Defu Zhi, Defeng Zhao

  KEYWORDS: Cationic Lipids; DNA Condensation; Gene Delivery; Transfection Efficiency

  JOURNAL NAME: Advances in Materials Physics and Chemistry, Vol.2 No.4B, January 17, 2013

  ABSTRACT: Design and synthesis of a carbamate-linked cationic lipid DDCTMA (N-[1-(2,3-didodecylcarbamoyloxy)propyl]-N,N,N-trimethylammonium iodide) as gene delivery carriers was described in this work. The transfection efficiency of cationic liposome increased dramatically with the increase in the content of DOPE. In addition, the transfection efficiency of some of cationic lipoplexes was superior or parallel to that of two commercial transfection agents, Lipofectamine2000 and DOTAP. The carbamate-linked cationic lipid DDCTMA/DOPE may be a promising gene carrier that has high transfection efficiency as well as low cytotoxicity.