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B. Andrea, V. Nicole, T. Jakob, H. Sonja, B. Stefan and E. M. Christa, “Synthesis and Pharmacological Evaluation of Coumarin Derivatives as Cannabinoid Receptor Antagonists and Inverse Agonists,” Bioorganic & Medicinal Chemistry, Vol. 17, No. 7, 2009, pp. 2842-2851. doi:10.1016/j.bmc.2009.02.027

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• TITLE: A Simple and Convenient Synthesis of Isolated-Fused Heterocycles Based on: 2-Imino-N-phenyl-2H-chromene-3-carboxamide

  AUTHORS: Islam H. El Azab, Fawi M. Abd El Latif Abd El Latif

  KEYWORDS: 2-Imino-2H-chromen-3-yl; Chromeno[2, 3-d]pyrimidin-4-one; β-Lactam; Thiazolidin-4-ones

  JOURNAL NAME: Open Journal of Synthesis Theory and Applications, Vol.1 No.3, October 31, 2012

  ABSTRACT: Starting from 2-imino-N-phenyl-2H-chromene-3-carbox-amide, (1) a series of functionalized chromenes were achieved; such as, 2-ethoxy-2,3-dihydro-3-phenylchromeno[2,3-d]pyrimidin-4-one (2), and 2-hydrazinyl-2,3-dihydro-3-phenylchromeno-[2,3-d]pyrimidin-4-one (3). Furthermore, reactions of (3) with some of laboratory available compounds gave pyrazoles (4-9, 12, 13a, 13b), tetrazoles (11), 2-(2-benzylidenehydrazinyl)-3-phenyl-3H-chromeno[2,3-d]pyrimidin4(10H)-oneisoxazoles (14), 5-chloro-1-(4-oxo-3-phenyl-4,10-dihydro-3H-chromeno[2,3-d]pyrimidin-2-yl)-3-phenyl-2, 3-dihydro-1H-pyrazole-4-carbonitrile (17), pyrimidines (28a, b), pyridines (29a-29e, 30, 33a, 33b), benzo[b][1, 4]oxazepin-2- amines (32a, b), 3-chloro-4-(2-imino-2H-chromen-3-yl)-1-phenyl-4-(phenylamino) azetidin-2-one (34a-34e) and 2-(2- imino-2H-chromen-3-yl)-3-phenyl-2-(phenyl amino)thiazolidin-4-onee (35a-35e). The structures of these compounds were established by elemental analysis, IR, MS and NMR spectral analysis.