TITLE:
Topical Preparation of Newer and Safer Analogs of N,N-diethyl-2-phenylacetamide (DEPA) against Aedes aegypti Mosquitoes
AUTHORS:
Akanksha Garud, Kumaran Ganesan, Navneet Garud, R. Vijayaraghavan
KEYWORDS:
Insect Repellent; Mosquitoes; Protection
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.1A,
January
10,
2013
ABSTRACT: Cosmetic acceptability and primary
skin irritation are the two main parameters for assessing the suitability of
any topical formulation meant for protection against the painful bites of
mosquitoes. In the present study four newer analogs of N,N-diethyl-2-phenylacetamide (DEPA), were
synthesized and formulated for topical application as insect repellent. They
were assessed for their irritant behavior on rabbit’s skin for erythema and
edema. The topical formulations of the analogs were also assessed for their
protection time at varying concentrations against Aedes aegypti mosquitoes.