TITLE:
Multiple Organ Dysfunction Syndrome (MODS): Is It Preventable or Inevitable?
AUTHORS:
Ayman El-Menyar, Hassan Al Thani, El Rasheid Zakaria, Ahmad Zarour, Mazin Tuma, Husham AbdulRahman, Ashok Parchani, Ruben Peralta, Rifat Latifi
KEYWORDS:
Multiorgan Dysfunction; Failure; Intensive Care Units
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.3 No.7A,
January
2,
2013
ABSTRACT: Multiple organ dysfunction
syndrome (MODS) is a systemic, dysfunctional inflammatory response that
requires long intensive care unit (ICU) stay. It is characterized with high
mortality rate depending on the number of organs involved. It has been
recognized that organ failure does not occur as an all-or-none rule, but rather
a range of organ dysfunction exists resulting in clinical organ failure. In the
absence of a gold standard scoring or tool for early diagnosis or prediction of
MODS, a novel bio-clinical scoring is mandatory. Moreover, understanding the
pathophysiology of MODS in medical, surgical and trauma, ICUs should take a priority to
achieve a favorable outcome. Herein we reviewed the literatures published in
English language through the research engines (MEDLINE, Scopus, and EBASE) from
1982 to 2011 using key words: “multiorgan dysfunction”, “organ failure”,
“intensive care units” to highlight the definition, mechanism, diagnosis and prediction of
MODS particularly at its earliest stages. Bring up new bio-clinical scoring to
a stage where it is ready for field trials will pave the way for implementing
new risk-stratification strategy in the intensive care to reduce the morbidity
and mortality and save resources. Prospective studies are needed to answer our
question and to shift MODS from an inevitable to a preventable disorder.