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Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., Wynshaw-Boris, A., Poli, G., Olefsky, J. and Karin, M. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nature Medicine, 11, 191-198. doi:10.1038/nm1185

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• TITLE: Is there any role of glucose-6-phosphate dehydrogenase in obesity induced metabolic disorder

  AUTHORS: Manisha Sankhla, Keerti Mathur, Jai Singh Rathor

  KEYWORDS: Obesity; Abdominal Adiposity; Oxidative Stress; Glucose-6-Phosphate Dehydrogenase; Adiponectin

  JOURNAL NAME: Health, Vol.4 No.12A, December 31, 2012

  ABSTRACT: The present study was designed to explore the possible mechanism of obesity associated metabolic syndrome. 150 subjects (120 men and 30 women) in the age-group of 17 - 26 years were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of generalized obesity and abdominal adiposity. The serum concentration of glucose-6-phosphate dehydrogenase increased with increasing levels of Body Mass Index and was found to be significant in obese subjects (Body Mass Index ≥ 30.0 kg/m2) and more so in the obese subjects with abdominal adiposity (p = 0.002) as compared to normal-weight subjects. Karl Pearson coefficient of correlation revealed a significant positive correlation of glucose-6-phosphate dehydrogenase with Body Mass Index (r = 0.499; p