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Yasukawa, T., Tokunaga, E., Ota, H., Sugita, H., Martyn, J.A. and Kaneki, M. (2005) S-nitrosylation dependent in- activation of AKt/protein kinase B in insulin resistance. Journal of Biological Chemistry, 280, 7511-7518. doi:10.1074/jbc.M411871200

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• TITLE: Is there any role of glucose-6-phosphate dehydrogenase in obesity induced metabolic disorder

  AUTHORS: Manisha Sankhla, Keerti Mathur, Jai Singh Rathor

  KEYWORDS: Obesity; Abdominal Adiposity; Oxidative Stress; Glucose-6-Phosphate Dehydrogenase; Adiponectin

  JOURNAL NAME: Health, Vol.4 No.12A, December 31, 2012

  ABSTRACT: The present study was designed to explore the possible mechanism of obesity associated metabolic syndrome. 150 subjects (120 men and 30 women) in the age-group of 17 - 26 years were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of generalized obesity and abdominal adiposity. The serum concentration of glucose-6-phosphate dehydrogenase increased with increasing levels of Body Mass Index and was found to be significant in obese subjects (Body Mass Index ≥ 30.0 kg/m2) and more so in the obese subjects with abdominal adiposity (p = 0.002) as compared to normal-weight subjects. Karl Pearson coefficient of correlation revealed a significant positive correlation of glucose-6-phosphate dehydrogenase with Body Mass Index (r = 0.499; p