TITLE:
Is there any role of glucose-6-phosphate dehydrogenase in obesity induced metabolic disorder
AUTHORS:
Manisha Sankhla, Keerti Mathur, Jai Singh Rathor
KEYWORDS:
Obesity; Abdominal Adiposity; Oxidative Stress; Glucose-6-Phosphate Dehydrogenase; Adiponectin
JOURNAL NAME:
Health,
Vol.4 No.12A,
December
31,
2012
ABSTRACT: The present study was
designed to explore the possible mechanism of obesity associated metabolic
syndrome. 150 subjects (120 men and 30 women) in the age-group of 17 - 26 years
were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of
generalized obesity and abdominal adiposity. The serum concentration of
glucose-6-phosphate dehydrogenase increased with increasing levels of Body
Mass Index and was found to be significant in obese subjects (Body Mass Index ≥
30.0 kg/m2) and more so in the obese subjects with abdominal
adiposity (p = 0.002) as compared to normal-weight subjects. Karl Pearson
coefficient of correlation revealed a significant positive correlation of
glucose-6-phosphate dehydrogenase with Body Mass Index (r = 0.499; p