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Grundy, S.M., Brewer Jr., H.B., Cleeman, J.I., Smith Jr., S.C. and Lenfant, C. (2004) Definition of metabolic syn- drome: Report of the National Heart, Lung and Blood In- stitute/American Heart Association, Conference on scien- tific issue related to definition. Circulation, 109, 433-438. doi:10.1161/01.CIR.0000111245.75752.C6

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• TITLE: Is there any role of glucose-6-phosphate dehydrogenase in obesity induced metabolic disorder

  AUTHORS: Manisha Sankhla, Keerti Mathur, Jai Singh Rathor

  KEYWORDS: Obesity; Abdominal Adiposity; Oxidative Stress; Glucose-6-Phosphate Dehydrogenase; Adiponectin

  JOURNAL NAME: Health, Vol.4 No.12A, December 31, 2012

  ABSTRACT: The present study was designed to explore the possible mechanism of obesity associated metabolic syndrome. 150 subjects (120 men and 30 women) in the age-group of 17 - 26 years were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of generalized obesity and abdominal adiposity. The serum concentration of glucose-6-phosphate dehydrogenase increased with increasing levels of Body Mass Index and was found to be significant in obese subjects (Body Mass Index ≥ 30.0 kg/m2) and more so in the obese subjects with abdominal adiposity (p = 0.002) as compared to normal-weight subjects. Karl Pearson coefficient of correlation revealed a significant positive correlation of glucose-6-phosphate dehydrogenase with Body Mass Index (r = 0.499; p