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C. Baldamus, S. Krivoshiev, M. Wolf-Pflugmann, M. Siebert-Weigel, R. Koytchev and A. Bronn, “Long-Term Safety and Tolerability of Epoetin Zeta, Administered Intravenously, for Maintenance Treatment of Renal Anemia,” Advances in Therapy, Vol. 25, No. 11, 2008, pp. 1215-1228. doi:10.1007/s12325-008-0111-1

has been cited by the following article:

• TITLE: Biosimilar Epoetin Zeta in Nephrology: Effect of Injection Frequency on Weekly Dose

  AUTHORS: Gerhard Lonnemann, Eike Wrenger

  KEYWORDS: Epoetin Zeta; Renal Anemia; Drug Efficiency; Injection Frequency; Chronic Hemodialysis

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.3 No.7, December 31, 2012

  ABSTRACT: Aim: This observational clinical study tested the effect of injection frequency of the biosimilar epoetin zeta on the weekly dose needed to maintain stable hemoglobin levels in chronic kidney diseases (CKD) patients on intermittent high-flux hemodialysis (HD). Patients and Methods: CKD patients (n = 33) on regular HD therapy 3 times a week were treated for 18 months with epoetin zeta i.v. The hemoglobin levels, the weekly dose as well as the injection frequency of epoetin zeta were monitored at least every two weeks. Patients were followed in three time periods: 1) extended follow-up (months 1 - 18); 2) intervention phase (months 19 - 21); and 3) post intervention observation phase (months 28 - 30). During extended follow-up the majority of patients (n = 21) received only one injection of epoetin zeta per week. During the intervention phase, injection frequency was increased to 3 injections per week in all patients accompanied by a reduction in weekly doses of approximately 20% - 30%. Following a 9 month period of dose adjustment all parameters were monitored again in the post-intervention phase. Results: During the first 18 months of epoetin zeta therapy the mean hemoglobin level was stable between 11 and 12 g/dl. The mean weekly dose of epoetin zeta was 7939 IU/week in month 6 and 7909 IU/week in month 18 (p = not significant). The mean frequency (injections/week) was 1.27 in month 6 and 1.29 in month 18 (not significant). Compared to month 18, at the end of the observation at month 30, hemoglobin levels were stable, mean injection frequency increased to 2.25 (p Conclusions: Increasing the injection frequency of the short acting biosimilar epoetin zeta to two to three injections per week reduces the weekly dose and thereby the costs of ESA therapy of renal anemia significantly.