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S. O. Ang, H. Chen, K. Hirota, V. R. Gordeuk, J. Jelinek, Y. Guan, E. Liu, A. I. Sergueeva, G. Y. Miasnikova, D. Mole, P. H. Maxwell, D. W. Stockton, G. L. Semenza, and J. T. Prchal., (2002) Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia, Nature Genet., 32, 614-621.

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• TITLE: Descriptively probabilistic relationship between mutated primary structure of von Hippel-Lindau protein and its clinical outcome

  AUTHORS: Shao-Min Yan, Guang Wu

  KEYWORDS: Amino Acid; Bayes’ Law; Cross-Impact Analysis; Distribution Probability; Mutation; Von Hip-pel-Lindau Disease

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.2 No.3, May 27, 2009

  ABSTRACT: In this study, we use the cross-impact analysis to build a descriptively probabilistic relationship between mutant von Hippel-Lindau protein and its clinical outcome after quantifying mutant von Hippel-Lindau proteins with the amino-acid distribution probability, then we use the Bayes-ian equation to determine the probability that the von Hippel-Lindau disease occurs under a mutation, and finally we attempt to distinguish the classifications of clinical outcomes as well as the endocrine and nonendocrine neoplasia induced by mutations of von Hippel-Lindau protein. The results show that a patient has 9/10 chance of being von Hippel-Lindau disease when a new mutation occurs in von Hippel- Lindau protein, the possible distinguishing of classifications of clinical outcomes using mod-eling, and the explanation of the endocrine and nonendocrine neoplasia in modeling view.