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B. S. Holla, B. Veerendra, M. K. Shivanada and B. Poojary, “Synthesis Characterization and Anticancer Activity Studies on Some Mannich Bases Derived from 1,2,4- Triazoles,” European Journal of Medicinal Chemistry, Vol. 38, No. 7-8, 2003, pp. 759-767. doi:10.1016/S0223-5234(03)00128-4

has been cited by the following article:

• TITLE: The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation

  AUTHORS: Wagnat W. Wardakhan, Sherif M. Sherif, Rafat M. Mohareb, Amr S. Abouzied

  KEYWORDS: Acetylhydrazine; Hydrazide-Hydrazone; Thiophene; Thiazole; Pyridine; Coumarin; Antitumor

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.4, December 27, 2012

  ABSTRACT: The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.