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S. Rollas, N. Kalyoncuoglu, D. Sur-Altiner and Y. Yegenoglu, “5-(4-Aminophenyl)-4-substituted-2,4-dihydro-3H- 1,2,4-triazole-3-thiones: Synthesis and Antibacterial and Antifungal Activities,” Pharmazie, Vol. 48, No. 4, 1993, pp. 308-309. doi:10.1016/S0223-5234(99)80048-8

has been cited by the following article:

• TITLE: The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation

  AUTHORS: Wagnat W. Wardakhan, Sherif M. Sherif, Rafat M. Mohareb, Amr S. Abouzied

  KEYWORDS: Acetylhydrazine; Hydrazide-Hydrazone; Thiophene; Thiazole; Pyridine; Coumarin; Antitumor

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.4, December 27, 2012

  ABSTRACT: The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.