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P. Greenberg, R. G. Parker, Y. Fu and E. Abemayor, “The Treatment of Solitary Plasmacytoma of Bone and Extramedullaryplasmacytoma,” American Journal of Clinical Oncology, Vol. 10, No. 3, 1987, pp. 199-204. doi:10.1097/00000421-198706000-00004

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• TITLE: Orbital Involvement in Multiple Myeloma: A Case Report

  AUTHORS: Sara Terenzi, Daniela di Cristino, Alessandra Murgia, Dania Janniello, Elisabetta Ponti, Barbara Tolu, Sara Cicchetti, Riccardo Santoni

  KEYWORDS: Plasma Cell Tumours; Multiple Myeloma; Tumours of the Orbit; Radiation Therapy

  JOURNAL NAME: Journal of Cancer Therapy, Vol.3 No.6, December 14, 2012

  ABSTRACT: Purpose: To report a retro-orbital localization of Multiple Myeloma (MM) describing its treatment and clinical result. Case report: A 50-years-old male patient with Magnetic Resonance Imaging (MRI) evidence of a retro-orbital mass with exophthalmos, due to the pathological diagnosis of MM, was referred for Radiation Therapy (RT). Discussion: The orbital involvement in Multiple Myeloma is rare and few cases are reported in the literature. The treatment of choice is RT alone with a prescribed dose ranging between 40 Gy and 45 Gy. In our patient the retro-orbital lesion, measuring 26 × 16 mm, was treated with Intensity Modulated Radiotherapy Technique (IMRT) delivering 4400 cGy with conventional fractionation. The treatment was well tolerated, the patient experienced a complete regression of the exophthalmos without any significant side effect.