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Y. K. Peterson, X. S. Wang, P. J. Casey and A. Tropsha, “Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structur-Activity Relationship Modeling, Virtual Screening, and Experimental Validation,” Journal of Medicinal Chemistry, Vol. 52, No. 14, 2009, pp. 4210-4220. doi:10.1021/jm8013772

has been cited by the following article:

• TITLE: Antiproliferative Properties of Vinyl Dipeptides: Synthesis and MCF-7 Cell Line Testing

  AUTHORS: Ashraf Hassan Bayoumi

  KEYWORDS: Piptidomimetics; Vinyl Dipeptides; 2-Aminopropenamide; Antiproliferative; Breast Cancer; Furan Derivatives

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.2 No.4, December 13, 2012

  ABSTRACT: Peptide mimics derived with close structure to peptide have vast utility because they are expected to interfere with biological targets while having superior drug-like properties if compared to peptides. In this work, novel vinyl dipeptides which are different in a double bond between the α-carbon of peptide and C1 of its side chain. Added to that, suitable substituents were selected to harness drug-like properties. The compounds were found to have moderate activities when tested against MCF-7 breast cancer cell line. For instance, the adamantyl analogue 2-(benzoylamino)-3-(2-furyl)-N-(1-adamantyl) propenamide (1c) and the heterocyclic analogue 2-(Benzoylamino)-3-(2-furyl)-N-[2-(5-cyanothia-zol-2-yl)] propenamide (1o) exhibited inhibition potency at 27.4 and 37.8 μM, respectively.