TITLE:
The Study of Influence of Silica and Polyethilene Glycols Organic-Inorganic Compounds on Free-Radical Processes in Vitro
AUTHORS:
Olga G. Sitnikova, Sergey B. Nazarov, Irina V. Shikhanova, Alexander V. Agafonov, Jean A. Dyuzhev, rina G. Popova
KEYWORDS:
Free-Radical Oxidation, Nanosilica, Chemiluminescence, Malonic Dialdehyde
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.1 No.2,
November
5,
2010
ABSTRACT: In this study investigation of influence of hybrid nanosilica-polyethylene glycols materials (molecular weight 1500, 6000 and 15000), prepared by sol-gel synthesis, on lipid peroxidation and antioxidant activity of human serum in vitro was performed. Methods included chemiluminescence analysis and quantitative malonic dialdehyde estimation. It was revealed that nanosilica-PEG materials with different molecular weight had certain biological activity. Powders of SiO2-PEG 1500 and SiO2-PEG 6000 manifest prooxidant effects, whereas mesoporous (calcine) powders produced antioxidant effects in blood serum in vitro.