TITLE:
Effects of methanolic extract of Pausinystalia yohimbe bark on blood glucose level in normal fasting rats
AUTHORS:
Hozeifa Mohamed Hassan, Taj Eldin Imad Mohamed, Elhadi Mohamed Mohamed Ahmed, Abd Elwahab Hassan Mohamed, Nizar Sirag
KEYWORDS:
Pausinystalia yohimbe Bark; Yohimbine; Fasting Blood Glucose Level; Hypoglycemia
JOURNAL NAME:
Health,
Vol.4 No.12,
December
10,
2012
ABSTRACT: Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels; such effect is unclear and remains requiring further studies.