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Santhosh, S., Sini, T.K., Anandan, R. and Mathee, P.T. (2007) Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats. European Journal of Pharmacology, 572, 69-73. doi:10.1016/j.ejphar.2007.05.059

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• TITLE: Schiff base SH11 with tuberculostatic and radical scavenging activities against INH-induced oxidative hepatic damage

  AUTHORS: Nedyalka Georgieva, Zvezdelina Yaneva, Galina Nikolova, Svetlana Simova

  KEYWORDS: INH; Schiff Base; Tuberculosis; EPR; Lipid Peroxidation; Antioxidant Enzymes

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.3 No.7A, November 30, 2012

  ABSTRACT: By in vitro visible electron paramagnetic resonance (EPR) spectrophotometry method we demonstrated that N-isonicotinoyl-N’-(3-etoxy-2-hydroxybenzaldehyd) hydrazone (SH11) exhibits radical scavenging activity (SSA). Malondialdehyde (MDA) in mice treated with INH was increased (2.578 ± 0.349 mM vs. 2.024 ± 0.164 μM, p SOD/mg Pr vs. 2.273 ± 0.317 USOD/mg Pr, p CAT/mg Pr, vs. 47.070 ± 16.490 UCAT/mg Pr, p