TITLE:
Schiff base SH11 with tuberculostatic and radical scavenging activities against INH-induced oxidative hepatic damage
AUTHORS:
Nedyalka Georgieva, Zvezdelina Yaneva, Galina Nikolova, Svetlana Simova
KEYWORDS:
INH; Schiff Base; Tuberculosis; EPR; Lipid Peroxidation; Antioxidant Enzymes
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.3 No.7A,
November
30,
2012
ABSTRACT: By in vitro visible electron paramagnetic resonance (EPR) spectrophotometry method we demonstrated that N-isonicotinoyl-N’-(3-etoxy-2-hydroxybenzaldehyd) hydrazone (SH11) exhibits radical scavenging activity (SSA). Malondialdehyde (MDA) in mice treated with INH was increased (2.578 ± 0.349 mM vs. 2.024 ± 0.164 μM, p SOD/mg Pr vs. 2.273 ± 0.317 USOD/mg Pr, p CAT/mg Pr, vs. 47.070 ± 16.490 UCAT/mg Pr, p