TITLE:
Platelet-Derived Microparticles in Patients with Colorectal Cancer
AUTHORS:
Violetta Dymicka-Piekarska, Mariusz Gryko, Alina Lipska, Aleksandra Korniluk, Elżbieta Siergiejko, Halina Kemona
KEYWORDS:
Microparticles; Platelets; Colorectal Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.3 No.6A,
November
30,
2012
ABSTRACT: Microparticles (MPs) are membrane vesicles released by platelets during activation or apoptosis. PMPs stimulate coagulation and cell adhesion to the vascular endothelium, both of which being important in the development of cancer progression. We investigated the correlation between microparticles and cancer advancement. The percentage of PMPs was measured by flow cytometry in 22 colorectal cancer patients and in 20 healthy subjects. The patients were divided into two groups according to the presence or lack of lymph node metastases. The percentage of PMPs was significantly higher in patients than in healthy subjects (p