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A. R. Katritzky, H. H. Odens, S. M. Zhang, C. J. Rostek and O. W. Maender, “Novel Syntheses of 2,3-Dihydro- 1,5-benzothiazepin-4(5H)-ones and 2H-1,4-benzothiazin- 3(4H)-ones,” Journal of Organic Chemistry, Vol. 66, No. 20, 2001, pp. 6792-6796. doi:10.1021/jo0101959

has been cited by the following article:

• TITLE: Synthesis and Trypanocidal Evaluation of Some Novel 2-(Substituted Benzylidene)-5, 7-Dibromo-6-Hydroxy-1-Benzofuran-3(2H)-Ones

  AUTHORS: K. L. Ameta, Nitu S. Rathore, Biresh Kumar, Edith S. Malaga M, Manuela Verastegui P, Robert H. Gilman, B. L. Verma

  KEYWORDS: Chalcones; Aurones; Trypanosoma cruzi; Chagas Disease; Inhibition

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.3A, November 29, 2012

  ABSTRACT: Substituted 2-benzylidene-1-benzofuran-3-ones are commonly known as aurones. This class of bioactive heterocycles belongs to flavonoid family. The article intends to put forth the rational design and synthesis of a new series of aurones using 3’,5’-dibromo-2’,4’-dihydroxychalcones and copper bromide in presence of DMF-water mixture (8:2, v/v) for the first time. Preliminary bioassay shows that most of compounds have good trypanocidal activity against Trypanosoma cruzi at 10 μg/mL. Few compounds are equally potent to the standard drugs Benznidazole and Nifurtimox. The structures of the newly synthesized products 2a-n were established by elemental analysis, FTIR, 1H NMR, 13C NMR and mass spectroscopic studies.