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Lindenbaum, J., Savage, D.G., Stabler, S.P. and Allen, R.H. (1990) Diagnosis of Cobalamin deficiency. II. Relative sensitivities of serum Cobalamin, methylmalonic acid and total homocysteine concentrations. American Journal of Hematology, 34, 99-107. doi:10.1002/ajh.2830340205

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• TITLE: M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

  AUTHORS: Rohit Jain, Menka Kapil, Gajendra Nath Gupta

  KEYWORDS: Vitamin B12; MCV; Deficiency; Prevalence; Investigation

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.2 No.4, November 29, 2012

  ABSTRACT: Introduction: A strict vegetarian diet has been associated with increased risk of cobalamin deficiency therefore; one would expect a high prevalence of Cobalamin deficiency in India. Erythrocyte indices have been used in the initial evaluation of anemic patients; high Mean corpuscular volume (MCV) is a traditional criterion for folate and vitamin B12 deficiencies. There is no large study of the prevalence of B12 deficiency among patients with normocytosis or micro-cytosis. Method: We retrospectively analyzed the records of serum vitamin B12 and MCV of both inpatients and outpatients at Santokba Durlabhji Memorial Hospital & Research Institute, Jaipur (Rajasthan) during the period from August 2010-April 2011. The study was aimed at identifying the correlation between vitamin B12 level and MCV; and prevalence of vitamin B12 deficiency in this region. Result & Conclusion: Every third person is vitamin B12 deficient in the region. There is no correlation between vitamin B12 levels and MCV in majority of the cases. MCV should not be the only criteria for ordering vitamin B12 for patients with anemia under evaluation.