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Loft, S., Danielsen, P., Lohr, M., Jantzen, K., Hemmingsen, J.G., Roursgaard, M., et al. (2012) Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA. Archives of Biochemistry and Biophysics, 518, 142-150. doi:10.1016/j.abb.2011.12.026

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• TITLE: Oxidative DNA damages by chemical exposures at work

  AUTHORS: Kyung-Taek Rim

  KEYWORDS: Oxidative DNA Damage; Industrial Chemicals; Chemoprevention; Workers; Health

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.3 No.7A, November 29, 2012

  ABSTRACT: Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Of the molecules subject to oxidative modification, DNA has received the greatest attention, with biomarkers of exposure and effect closest to validation. There are many chemicals in workplaces that could cause oxidative DNA damages such as carcinogens. This review concentrated on studies published between the years 2000 and 2012 that used to detect 8-oxodG in humans (workers), laboratory animals and in cell lines. Given the recent toxicological results from oxidative stress, it is important to review these studies to improve the current understanding of the oxidative DNA damages by chemical exposures at work. It also suggests that biomarkers may be responsible for understanding the role of oxidative DNA damage in disease, highlighting the need for further studies.