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Hirota, M., Inoue, M., Ando, Y., Hirayama, K., Morino, Y., Sakamoto, K., Mori, K. and Akagi, M. (1989) Inhibition of stress-induced gastric injury in the rat by glutathione. Gastroenterology, 97, 853-859.

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• TITLE: Protective effect of fermented papaya preparation on stress-induced acute gastric mucosal lesion

  AUTHORS: Shinki Murakami, Fusako Takayama, Toru Egashira, Mitsuko Imao, Akitane Mori

  KEYWORDS: Acute Gastric Mucosal Lesion; Fermented Papaya Preparation; Oxidative Stress; Inflammation

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.4, November 29, 2012

  ABSTRACT: Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investigated the protective effects and the mechanism of action of FPP on stress-induced AGML in rats, induced by water immersion restraint stress (WIRS). Exposure of rats to 6-hour WIRS resulted in the appearance of splinter hemorrhages and mucosal lesions in the stomach. WIRS induced significant increase in lipid peroxidation and decrease in superoxide dismutase-like activity in both the plasma and gastric mucosa. WIRS also significantly increased myeloperoxidase activity together with Nuclear factor-kappaB (NF-kB) activation in gastric mucosa. FPP reduced all the above changes. The results suggest that oral administration of FPP provides protection against WIRS-induced acute gastric mucosal lesions through its anti-oxidative and anti-inflammatory properties.