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Morris, J.S., Smith, K.A., Cowen, P.J., Friston, K.J. and Dolan, R.J. (1999) Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. Neuroimage, 10, 163-172. doi:10.1006/nimg.1999.0455

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• TITLE: The interaction between the dopaminergic and the serotonergic systems in the 6-OHDA rat model of Parkinson’s disease

  AUTHORS: Daphna Sourani, Gadi Goelman

  KEYWORDS: Parkinson’s Disease; Depression; 6-Hydroxydopamine; Lateral Habenula; Manganese-Enhanced-MRI

  JOURNAL NAME: Health, Vol.4 No.11A, November 29, 2012

  ABSTRACT: This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.