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Zigmond, M.J., Abercrombie, E.D., Berger, T.W., Grace, A.A. and Stricker, E.M. (1990) Compensations after lesions of central dopaminergic neurons: Some clinical and basic implications. Trends in Neurosciences, 13, 290-296. doi:10.1016/0166-2236(90)90112-N

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• TITLE: The interaction between the dopaminergic and the serotonergic systems in the 6-OHDA rat model of Parkinson’s disease

  AUTHORS: Daphna Sourani, Gadi Goelman

  KEYWORDS: Parkinson’s Disease; Depression; 6-Hydroxydopamine; Lateral Habenula; Manganese-Enhanced-MRI

  JOURNAL NAME: Health, Vol.4 No.11A, November 29, 2012

  ABSTRACT: This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.