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Herv′e, D., Pickel, V.M., Joh, T.H. and Beaudet, A. (1987) Serotonin axon terminals in the ventral tegmental area of the rat: Fine structure and synaptic input to dopaminergic neurons. Brain Research, 435, 71-83. doi:10.1016/0006-8993(87)91588-5

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• TITLE: The interaction between the dopaminergic and the serotonergic systems in the 6-OHDA rat model of Parkinson’s disease

  AUTHORS: Daphna Sourani, Gadi Goelman

  KEYWORDS: Parkinson’s Disease; Depression; 6-Hydroxydopamine; Lateral Habenula; Manganese-Enhanced-MRI

  JOURNAL NAME: Health, Vol.4 No.11A, November 29, 2012

  ABSTRACT: This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.