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P. Ceppi, M. Volante, A. Ferrero, et al., “Thymidylate Synthase Expression in Gastroenteropancreatic and Pulmonary Neuroendocrine Tumors,” Clinical Cancer Research, Vol. 14, No. 4, 2008, pp. 1059-1064. doi:10.1158/1078-0432.CCR-07-1513

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• TITLE: Unexpected Dramatic Response of Pretreated Invasive Thymic Malignancies on Pemetrexed-Case Report and Review of Current Treatment Modalities

  AUTHORS: Priscilla Raman, Veerle Surmont

  KEYWORDS: Thymoma; Pemetrexed; Thymic Carcinoma; Combined Modality Therapy; Molecular Targeted Therapy

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.2 No.4, November 27, 2012

  ABSTRACT: Thymomas are rare and usually slowly growing tumors, originating from the epithelial layer of the thymus. Prognosis depends on the extent of invasion of adjacent tissues whereby multimodality treatment including surgery with or without adjuvant chemoradiotherapy is the preferred approach for locally advanced thymomas. For metastatic thymomas, only few chemotherapeutic options are available. We report 2 cases of patients with metastatic thymic malignancies with a dramatic response on pemetrexed treatment. The choice for this antifolate therapy is based upon a small series. Because metastatic thymic neoplasm is a rare disease, large randomised trials are not feasible. Case reports on the treatment of these malignancies are very important and can provide readers with the opportunity to deal with rare dis- eases.