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Y. B. Pride, S. D. Wiviott, J. L. Buros, C. Zorkun, M. U. Tariq, E. M. Antman, E. Braunwald and C. M. Gibson, “Effect of Prasugrel versus Clopidogrel on Outcomes among Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention without Stent Implantation: A Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel (TRITON)-Thrombolysis in Myocardial Infarction (TIMI) 38 Substudy,” American Heart Journal, Vol. 158, No. 3, 2009, pp. e21-e26.

has been cited by the following article:

• TITLE: Clinical Analysis of the Pharmacological Interactions of Clopidogrel and Gender Differences: A Case-Control Study

  AUTHORS: Bianchi Stefano, Chiara Casellato, Bianchini Erica, Scanavacca Paola

  KEYWORDS: Antiplatelet Activity; Plus Proton-Pump Inhibitors; Gender

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.3 No.6, November 27, 2012

  ABSTRACT: Background: Clopidogrel is a prodrug metabolized by cytochrome P450-2C19. Drugs inhibiting this enzyme might reduce its antiplatelet activity. In order to reduce gastrointestinal bleedings, proton-pump inhibitors are usually prescribed in association with clopidogrel. The study aims at assessing the clinical importance of interactions between clopidogrel and inhibitors of CYP2C19. It also aims to evaluate any possible factors that may reduce the therapeutic efficacy of the drug. Particular attention was devoted to possible gender differences in responsiveness to treatment with clopidogrel or clopidogrel plus proton-pump inhibitors. This analysis is a retrospective case-control observational study carried out by the University Hospital of Ferrara. Methods: Subjects were patients who had received clopidogrel from 01-01-2008 to 31-12-2008. For them, we analysed hospital admissions and data of drug prescriptions relative to dispensing of drugs cytochrome P-450-2C19 inhibitors. Patients were subdivided into case and control groups based on the occurrence or not of cardiovascular or cerebrovascular secondary events during therapy with clopidogrel. Results: The study focused on 781 patients, 20.1% of which (n.157) experienced secondary effects. The mean age is 70 years old. Men (67% of the analyzed population) experienced secondary events more than women (OR 1.54; CI 95% 1.04 - 2.28; p