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Silver, F.L., Mackey,A., Clark,W.M., Brooks, W., Timaran, C.H., Chiu, D., Goldstein, L.D., Meschia, J. F., Ferguson, R.D., Moore, W.S., Howard, G. and Brott, T.G. (2011) Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Stroke, 42, 675- 680. doi:10.1161/STROKEAHA.110.610212

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• TITLE: Transcatheter treatment of atherosclerotic lesions of the brain complicated by vascular dementia development

  AUTHORS: Ivan V. Maksimovich

  KEYWORDS: Cerebrovascular Disease; Vascular Dementia; Cognitive Impairment; Stroke; Transcatheter Treatment; Laser Revascularization; Regeneration

  JOURNAL NAME: World Journal of Neuroscience, Vol.2 No.4, November 26, 2012

  ABSTRACT: The research focuses on the effectiveness of transluminal laser revascularization of the brain in the treatment of atherosclerotic lesions accompanied by vascular dementia development. 1125 patients aged from 29 to 81 (average age 75) suffering from various kinds of atherosclerotic lesions of cerebral vessels were examined during the research. The examination plan included: computed tomography of the brain (CT), magnetic resonance imaging (MRI), scintigraphy of the brain (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA). 665 (59.11%) patients suffered from diseases accompanied by the development of vascular dementia. To perform transcatheter treatment, 639 patients were selected: Group 1 (CDR-1)—352 patients, Group 2 (CDR-2)—184 patients, Group 3 (CDR-3)—103 patients. To conduct revascularization of main intracranial arteries high-energy laser systems were used; for revascularization of the distal intracranial branches low-energy laser systems were used. The clinical outcome depended on the severity of dementia and the timing of the intervention. A good clinical outcome in Group 1 was obtained in 281 (79.82%) cases, in Group 2 in 81 (44.02%) cases, in Group 3 in 9 (8.73%) cases. A satisfactory clinical outcome in Group 1 was obtained in 53 (15.34%) cases, in Group 2 in 62 (33.70%) cases, in Group 3 in 31 (30.09%) cases. A relatively satisfactory clinical outcome in Group 1 was obtained in 17 (4.83%) cases, in Group 2 in 41 (22.28%) cases, in Group 3 in 63 (61.16%) cases. No negative effect was observed after the intervention. Evaluating the data obtained it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of atherosclerotic lesions of the brain accompanied by dementia.