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M. L. Scherzer, I. Liehneova, F. J. M. Negrete and D. Schnober, “Combinazione Fissa Travoprost 0.004%/ Timololo 0.5% Nei Pazienti in Transizione Terapeutica da Bimatoprost 0.03%/Timololo 0.5% Combinazione Fissa o Non Fissa,” Advances in Therapy, Vol. 28, No. 8, 2011, pp. 661-670. doi:10.1007/s12325-011-0043-z

has been cited by the following article:

• TITLE: Comparative Evaluation of the Efficacy of the Bimatoprost 0.03%, Brimonidine 0.2%, Brinzolamide 1%, Dorzolamide 2%, and Travoprost 0.004%/Timolol 0.5%-Fixed Combinations in Patients Affected by Open-Angle Glaucoma

  AUTHORS: Italo Giuffre

  KEYWORDS: Bimatoprost 0.03%; Brimonidine 0.2%; Brinzolamide 1%; Dorzolamide 2%, Travoprost 0.004%/Timolol 0.5% Fixed Combinations; Efficacy; IOP

  JOURNAL NAME: Open Journal of Ophthalmology, Vol.2 No.4, November 23, 2012

  ABSTRACT: Purpose: This is a retrospective, comparative, head-to-head, not commissioned study about the efficacy of bimato-prost 0.03%, brimonidine 0.2%, brinzolamide 1%, dorzolamide 2%, and travoprost 0.004%/timolol 0.5%-fixed combinations in patients affected by na?ve open-angle glaucoma and IOP > 25 mmHg. Patients and Methods: Files from 70 patients (35 M, 35 F, mean age 69.52 y, S.D. 11.56, range: 37-87y) in our Glaucoma Service were retrospectively analyzed as long as 12 months. Every subgroup, including 14 age- and sex-matched patients, was allocated to 1 of the 5 groups of the fixed combinations monotherapy. Data recorded after 3 months follow-up were statistically analyzed by descriptive and ANOVA statistics as percentage of IOP reduction from baseline. Results: All the fixed combinations were effective in lowering IOP. The mean percentage reduction was: brimonidine/timolol 43.57%, dorzolamide/timolol 37.67%, bimatoprost/timolol 35.60%, travoprost/timolol 33.25% and brinzolamide/timolol 23.0%. The brimonidine/timolol fixed combination showed to be statistically significant more effective only than brinzolamide/timolol fixed combination (p = 0.001). Setting the α error to 5%, the power of the study is 26%, phi: 0.842. Discussion: In all this cohort of patients the target IOP was successfully achieved. All the fixed combinations used in this study had a very good profile of efficacy. Brimonidine, dorzolamide, bimatoprost and travoprost/timolol fixed combinations statistically significantly reduced the percentage of IOP from baseline (p = 0.001) more than brinzolamide/timolol fixed combination.