TITLE:
Fe2+ Coupled with Vitamin c (Vc) Can Enhance Glucose Metabolism and Decrease Blood Glucose Levels of Alloxan-Induced Diabetic Mice
AUTHORS:
Huihua Zhen, Hui Chen, Zhenle Tian, Zhicai Zhang
KEYWORDS:
Glucose Metabolism; Glucose Consumption; FeSOsub>4; Oxidant Stress; Vc
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.3 No.11,
November
23,
2012
ABSTRACT: That FeSO4 not
FeCl3 can reduce the blood glucose levels of alloxan-induced
diabetes mice has been reported in previous research. This study explained the
cause of difference in activity of two different iron ions on diabetic mice
based on glucose consumption (GC). FeSO4, FeCl3, Vitamine
c (Vc), FeSO4 + Vc, metformin were
administrated to the alloxan induced-diabetic mice, respectively. After administrated, serum
glucose, fructosaminr, insulin, triglyceride, total cholesterol, total iron and
Fe2+ levels and GC of liver in
vivo were analyzed, respectively. In
vitro, effect of different iron ions coupled with Vc or streptozotocin on
GC of liver of diabetic mice of model group were analyzed. The body weights and
serum insulin levels of Fe2+ and Fe2+ + Vc treated diabetic mice notably
increased. The serum glucose, fructosamine, triglyceride and total cholesterol levels
were significantly decreased, whereas serum total iron and Fe2+ levels and GC in liver were increased in the Fe2+, Vc and Fe2+ + Vc groups compared with in the model
groups. In addition,
hardly change of serum insulin level was caused by Fe2+, Vc and Fe2+ + Vc treatment. However, the similar resultst
did not obtain a Fe3+ treated. Further, liver’s GC of untreated-diabetic mice was lower than of
normal mice and significantly increased after Fe2+ not Fe3+ added to the reaction resolution in vitro,
and further increased when Fe2+ and vitamin c (Vc) synchronously
added to the reaction system, however, decreased when Fe2+ and Streptozotocin
were added synchronously to the reaction resolution. It is suggested that iron
coupled with reducer can enhance the glucose metabolism to eventually achieve
to controlling blood glucose levels.