TITLE:
A case of a patient positive for anti-cardiolipin antibodies with recurrent fetal wastage and cerebral infarction who was successfully treated with Sairei-to, low dose aspirin, and heparin
AUTHORS:
Taro Nonaka, Makoto Chihara, Izumi Ooki, Masaki Tamura, Takumi Kurabayashi, Koichi Takakuwa
KEYWORDS:
Anti-Cardiolipin Antibody; Postpartum Cerebral Hemispheric Infarction; Abnormal Pregnancy; Sairei-to; Low Dose Aspirin
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.2 No.4,
November
20,
2012
ABSTRACT: We report a successful case of a pregnant female positive for anti-cardiolipin antibodies who experienced two abnormal pregnancies with postpartum cerebral hemispheric infarctions. A 38-year-old female diagnosed as being positive for anti-cardiolipin antibodies was referred to our hospital due to her strong desire to have a baby. The administration of Japanese herbal medicine, Sairei-to, as immunosuppressive therapy, and low dose aspirin, as anti-coagulation therapy, were initiated prior to the patient’s pregnancy. Five months after beginning the treatment, the patient conceived spontaneously. At 34 weeks of gestation, emergency cesarean section was performed due to increasing genital bleeding resulting from coincidental placenta previa and the patient delivered an appropriate-for-date female infant (1970 g). Treatment with Japanese herbal medicine (Sairei-to) and low-dose aspirin is considered to be an effective treatment option for patients positive for anti-phospholipid antibodies with past histories of abnormal pregnancies.