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K. Uchida, “A Lipid-Derived Endogenous Inducer of COX-2: A Bridge between Inflammation and Oxidative Stress,” Molecular Cell, Vol. 25, No. 3, 2008, pp. 347-351.

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• TITLE: In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-Ay Mice

  AUTHORS: Sayaka Iwasaki, Made Airanthi Kusum Widjaja-Adhi, Ai Koide, Takerou Kaga, Seita Nakano, Fumiaki Beppu, Masashi Hosokawa, Kazuo Miyashita

  KEYWORDS: Fucoxanthin; In Vivo Antioxidant Activity; Anti-Diabetic Effect; KK-Ay Mice

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.11, November 19, 2012

  ABSTRACT: Dietary intake of 0.1% fucoxanthin significantly reduced lipid hydroperoxide levels of liver and abdominal white adipose tissue (WAT) of obese/diabetes KK-Ay mice. The fucoxanthin supplementation also significantly reduced blood glucose level and hepatic lipid contents of the mice. Oxidative stress is known to be induced in hyperglycemia and high fat conditions. Therefore, in vivo antioxidant activity of fucoxanthin found in the present study could be attributed to its anti-diabetic effect and its decreasing effect on hepatic lipids. On the other hand, little effect of fucoxanthin on lipid hydroperoxide levels was found in normal ICR mice. Although the content of fucoxanthin metabolites in the abdominal WAT of KK-Ay mice was about 50 times higher that in the liver, there was little difference in its In Vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its In Vivo antioxidant activity.