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Zhang, J.J., Ding, E.L. and Song, Y.Q. (2006) Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events. Clinician’s Corner, 296, 1619-1632.

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• TITLE: Psychotropic effects of aspirin, acetylsalicylate cobalt and acetylsalicylate zinc at various doses

  AUTHORS: Tatyana V. Yakovchyuk, Oksana V. Katiushyna, Ivan I. Koreniuk, Denis R. Khusainov, Tatyana V. Gamma

  KEYWORDS: Acetylsalicylic Acid; Acetylsalicylate Cobalt; Acetylsalicylate Zinc; Psychotropic Action, Behavioral Tests; Ultra-Low Doses; Rats

  JOURNAL NAME: Health, Vol.4 No.11, November 16, 2012

  ABSTRACT: For the first time it is shown that psychotropic action of acetylsalicylates at various doses is manifested as a nonmonotonic dependence having its peaks at therapeutic and ultra-low dose zones. It is discovered that development of effects of aspirin resembles that of acetylsalicylate zinc. Acetylsalicylate cobalt at extremely low doses zone showed the highest antidepressant activity, demonstrating toxicity at high doses. Generally, it is revealed that the use of aspirin and its salts at high doses range causes maximum psychotropic effects development, usually accompanied by side-effects. Therefore, aspirin, acetylsalicylate cobalt and zinc at extremely low doses are recommended for further study as psychotropic medications.