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Hothorn, L.A., Sill, M. and Schaarschmidt, F. (2010) Evaluation of incidence rates in pre-clinical studies using a Williams-type procedure. The International Journal of Biostatistics, 6, 1557-4679. Hdoi:10.2202/1557-4679.1180

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• TITLE: Pairwise comparisons in the analysis of carcinogenicity data

  AUTHORS: Mohammad A. Rahman, Ram C. Tiwari

  KEYWORDS: Carcinogenicity Study; Trend Test; Pairwise Test; Exact Test

  JOURNAL NAME: Health, Vol.4 No.10, November 1, 2012

  ABSTRACT: Analysis of carcinogenicity data generally involves a trend test across all dose groups and a pairwise comparison of the high dose group with the control. The most commonly used test for a positive trend is the Cochran-Armitage test. This test is asymptotically normal. For the pairwise comparison of the high dose group with the control group, we propose two modifications: the first modification is to apply the test on the data from high dose and control groups after dropping the data from the low and the medium dose groups; the second modification is to adjust the test conditional on data from all dose groups. We compare the power performance of these two modifications for the pairwise comparisons.