TITLE:
Pairwise comparisons in the analysis of carcinogenicity data
AUTHORS:
Mohammad A. Rahman, Ram C. Tiwari
KEYWORDS:
Carcinogenicity Study; Trend Test; Pairwise Test; Exact Test
JOURNAL NAME:
Health,
Vol.4 No.10,
November
1,
2012
ABSTRACT: Analysis of carcinogenicity data generally involves a trend test across all dose groups and a pairwise comparison of the high dose group with the control. The most commonly used test for a positive trend is the Cochran-Armitage test. This test is asymptotically normal. For the pairwise comparison of the high dose group with the control group, we propose two modifications: the first modification is to apply the test on the data from high dose and control groups after dropping the data from the low and the medium dose groups; the second modification is to adjust the test conditional on data from all dose groups. We compare the power performance of these two modifications for the pairwise comparisons.