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Chillon M, Dork T, Casals T et al. A novel donor splice site in intron 11 of the CFTR gene, created by mutation 1811+1.6kbA-->G, produces a new exon: high frequency in Spanish cystic fibrosis chromosomes and association with severe phenotype, Am J Hum Genet 1995;56:623-629.

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• TITLE: Genetic variation may play a crucial role in non-coding RNA biogenesis

  AUTHORS: Jeyalakshmi Kandhavelu, Meenakshisundaram Kandhavelu

  KEYWORDS: Genome Wide Analysis; Bioinformatics; Genetic Variation; Non-Coding RNA Biogenesis; RNA Structure; Speciation

  JOURNAL NAME: American Journal of Molecular Biology, Vol.2 No.4, October 31, 2012

  ABSTRACT: Transcription, post-transcriptional modification, translation, post-translational modification, DNA replication, and signaling interaction of intra- and extra- cellular components are the relevant mechanisms in gene regulation. Transcription is one of the most important mechanisms in the control of gene expression. Further, post-transcriptional modifications play a crucial role after transcription which determine whether the transcribed gene is coding or non-coding RNA (ncRNAs). Genome-wide analysis of RNAs provides information about the coding RNAs, whereas the status of ncRNAs are still at large and must be discussed in detail as variations in the ncRNAs can lead to different phenotypes. In this short article, we discuss the role of genetic variation in ncRNA genes and how this variation may play a crucial role in ncRNA biogenesis that eventually leads to phenotypic variation and thus speciation.