Article citationsMore>>

K. Oshima, Y. Naoi, K. Kishi, et al., “Gene Expression Signature of TP53 But Not Its Mutation Status Predicts Response to Sequential Paclitaxel and 5-FU/Epirubicin/Cyclophosphamide in Human Breast Cancer,” Cancer Letters, Vol. 307, No. 2, 2011, pp. 149-157.doi:10.1016/j.canlet.2011.03.027

has been cited by the following article:

• TITLE: p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age-Related and Racial Differences

  AUTHORS: Simone Davion, Megan Sullivan, Stephen Rohan, Kalliopi P. Siziopikou

  KEYWORDS: Triple Negative Breast Cancer; p53; Race; Age

  JOURNAL NAME: Journal of Cancer Therapy, Vol.3 No.5A, October 31, 2012

  ABSTRACT: Triple negative breast carcinomas (TNBC), are defined by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression. The majority of TNBC are “basal-like”, a group originally defined by studies of mRNA gene expression profiles, but increasingly defined in the clinic by using surrogate markers such as CK 5/6. However, not all TNBC are basal-like. It is postulated that these subcategories of TNBC have distinct underlying biologies that drive their ultimate behavior, and response to treatment, with important implications for designing appropriate targeted therapies. In this study we report that within our cohort of 197 TNBC, distinct groups were identified that varied by CK 5/6 and p53 expression based on age and race. We propose that awareness of CK5/6 and p53 expression in younger and AA TNBC patients may facilitate identifying patients with unique tumor subtypes and may lead to better use of targeted therapies in this group of aggressive breast cancers.