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E. Topo, A. Soricelli, A. D’Aniello, S. Ronsini and G. D’Aniello, “The Role and Molecular Mechanism of DAspartic Acid in the Release and Synthesis of LH and Testosterone in Humans and Rats,” Reproductive Biology Endocrinology, Vol. 7, No. 1, 2009, pp. 120-131. doi:10.1186/1477-7827-7-120

has been cited by the following article:

• TITLE: D-Aspartate, a Key Element for the Improvement of Sperm Quality

  AUTHORS: Gemma D’Aniello, Salvatore Ronsini, Tiziana Notari, Natascia Grieco, Vincenzo Infante, Nicola D’Angel, Fara Mascia, Maria Maddalena Di Fiore, George Fisher, Antimo D’Aniello

  KEYWORDS: D-Aspartate; Oligo-Asthenozoospermia; Asthenozoospermia; Pregnancies

  JOURNAL NAME: Advances in Sexual Medicine, Vol.2 No.4, October 31, 2012

  ABSTRACT: Introduction: D-Aspartate is an endogenous amino acid involved in LH and testosterone release in humans. In this study we investigate the impact of nutritional supplementation of sodium D-aspartate on the improvement of sperm quality in sub-fertile patients and the rate of pregnancies that occurred with their partners. Materials and Methods: A group of 30 patients affected by oligo-asthenozoospermia and a group of 30 patients affected by asthenozoospermia were treated with a daily dose of sodium D-aspartate for 90 days. After which, the change in spermatozoa concentration and their motility and the pregnancies that occurred with their partners were recorded. Results: We found that the supplementation of D-aspartate significantly increased the concentration and the motility of spermatozoa. In oligo- asthenozoospermic patients the increase of sperm concentration was found to be 2.0-fold, P Conclusions:Treatment of sub-fertile patients with sodium D-aspartate improved the number and the motility of the spermatozoa and consequently improved the rate of pregnancies of their partners.