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A. Lenzi, P. Sgrò, P., Salacone, D. Paoli, B Gilio, et al., “A Placebo-Controlled Double Blind Randomized Trial of the Use of Combined L-Carnitine and L-Acetyl-carnitine Treatment in Men with Asthenozoospermia,” Fertility Sterility, Vol. 81, No. 6, 2004, pp.1578-1584. doi:10.1016/j.fertnstert.2003.10.034

has been cited by the following article:

• TITLE: D-Aspartate, a Key Element for the Improvement of Sperm Quality

  AUTHORS: Gemma D’Aniello, Salvatore Ronsini, Tiziana Notari, Natascia Grieco, Vincenzo Infante, Nicola D’Angel, Fara Mascia, Maria Maddalena Di Fiore, George Fisher, Antimo D’Aniello

  KEYWORDS: D-Aspartate; Oligo-Asthenozoospermia; Asthenozoospermia; Pregnancies

  JOURNAL NAME: Advances in Sexual Medicine, Vol.2 No.4, October 31, 2012

  ABSTRACT: Introduction: D-Aspartate is an endogenous amino acid involved in LH and testosterone release in humans. In this study we investigate the impact of nutritional supplementation of sodium D-aspartate on the improvement of sperm quality in sub-fertile patients and the rate of pregnancies that occurred with their partners. Materials and Methods: A group of 30 patients affected by oligo-asthenozoospermia and a group of 30 patients affected by asthenozoospermia were treated with a daily dose of sodium D-aspartate for 90 days. After which, the change in spermatozoa concentration and their motility and the pregnancies that occurred with their partners were recorded. Results: We found that the supplementation of D-aspartate significantly increased the concentration and the motility of spermatozoa. In oligo- asthenozoospermic patients the increase of sperm concentration was found to be 2.0-fold, P Conclusions:Treatment of sub-fertile patients with sodium D-aspartate improved the number and the motility of the spermatozoa and consequently improved the rate of pregnancies of their partners.