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Pellegrini, M.C., Liang, H., Mandiyan, S., Wang, K., Yuryev, A., Vlattas, I., Sytwu, T., Li, Y.-C. and Wennogle, L.P. (1998) Mapping the subsite preferences of protein tyrosine phosphatase PTP-1B using combinatorial chemistry approaches. Biochemistry, 37, 15598-15606. doi:10.1021/bi981427+

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• TITLE: Changes in protein tyrosine phosphatase activity in Spontaneously Diabetic Torii (SDT) rats

  AUTHORS: Takayuki Yamaguchi, akeshi Ohta, Hisayo Morinaga, Takahiro Hata, Eimei Sato, Mutsuyoshi Matsushita

  KEYWORDS: Fat; PTPase; SDT Rat

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.2 No.4, October 31, 2012

  ABSTRACT: The Spontaneously Diabetic Torii (SDT) rat is a nonobese type 2 diabetic model, showing the overt hyperglycemia after about 16 weeks of age. In this study, we investigated the protein tyrosine phosphatase (PTPase) activities in insulin-sensitive tissues in SDT rats. PTPase activities in the liver, muscle, and fat were examined at 8 weeks (pre-diabetes), 16 weeks (onset-diabetes), and 24 weeks (diabetes). SDT rats showed glucose intolerance at 8 weeks and hyperglycemia after 16 weeks. The PTPase activities in fat increased at 8 weeks and the increase was sustained to 24 weeks. In the liver, PTPase activities increased only at 24 weeks. On the other hand, the PTPase activities in muscle did not change. The increase of PTPase activity in fat might be related to progression of glucose intolerance and diabetes in SDT rats.