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A. Palumbo, F. Gay, P. Falco, C. Crippa, V. Montefusco, F. Patriarca, F. Rossini, S. Caltagirone, G. Benevolo, N. Pescosta, T. Guglielmelli, S. Bringhen, M. Offidani, N. Giuliani, M. T. Petrucci, P. Musto, A. M. Liberati, G. Rossi, P. Corradini and M. Boccadoro, “Bortezomib as Induction before Autologous Transplantation, Followed by Lenalidomide as Consolidation-Maintenance in Untreated Multiple Myeloma Patients,” Journal of Clinical Oncology, Vol. 28, No. 5, 2010, pp. 800-807.

has been cited by the following article:

• TITLE: Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone

  AUTHORS: Masao Hagihara, Morihiro Inoue, Jian Hua, Nobuyasu Iwaki, Kosuke Yoshioka, Takeshi Kobayashi

  KEYWORDS: Plasmacytoma; Testis; Lenalidomide

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.4, October 31, 2012

  ABSTRACT: We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.